Epigenetics, Nuclear Organization & Gene Function: With implications of epigenetic regulation and genetic architecture for human development and health

Epigenetics, Nuclear Organization & Gene Function: With implications of epigenetic regulation and genetic architecture for human development and health, 1 is a comprehensive biology reference published by Oxford University Press. Description Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. These changes, consisting principally of DNA methylation, histone modifications, and non-coding RNAs, maintain or modulate the initial impact of regulatory factors that recognize and associate with particular genomic sequences.

Key Features

- Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence
- These changes, consisting principally of DNA methylation, histone modifications, and non-coding RNAs, maintain or modulate the initial impact of regulatory factors that recognize…
- Epigenetic modifications are manifest in all aspects of normal cellular differentiation and function, but they can also have damaging effects that result in pathologies such as…
- Research is continuously uncovering the role of epigenetics in a variety of human disorders, providing new avenues for therapeutic interventions and advances in regenerative…
- This book's primary goal is to establish a framework that can be used to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and…
- A further aim is to highlight the role played by the three-dimensional organization of the genetic material itself (the complex of DNA, histones and non-histone proteins referred…
- This architectural organization of the genome plays a major role in the subsequent retrieval, interpretation, and execution of both genetic and epigenetic information

Product Details

Publisher: Oxford University Press
Edition: 1
Format: Publisher PDF
File Size: 100 MB
ISBN: 9780198831211